Updated Clinical Practice Guideline: Pharmacologic Management of Newly Detected Atrial Fibrillation (Frost et al, 2017)

Guidelines/Clinical Documents: To review the evidence and provide clinical recommendations for the pharmacologic management of atrial fibrillation. Methods: This guideline is based on two systematic reviews of published randomized controlled trials (RCTs) and prospective and retrospective observational studies from 2000 to 2012. An updated literature search was performed to identify new studies from 2012 to December 31, 2015. The targeted audience for the guideline includes all primary care clinicians, and the targeted patient population includes adults who have nonvalvular atrial fibrillation that is not due to a reversible cause. This guideline was developed using a modified version of GRADE to evaluate the quality of the evidence and make recommendations based on the balance of benefits and harms.